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  Title	Earnings call transcript: Aytu BioPharma's Q1 2025 shows stable stock
  ID	27734973
  External ID	2dacb581ee9f60264e2a81ca9cf5ab76
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  Published Date	Nov. 13, 2025, 5:16 p.m.
  Summary	Earnings call transcript: Aytu BioPharma's Q1 2025 shows stable stock
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  URL	https://www.investing.com/news/transcripts/earnings-call-transcript-aytu-biopharmas-q1-2025-shows-stable-stock-93ch-4357465
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  Content	Aytu BioPharma reported its first-quarter earnings for 2025, showcasing a mixed financial performance. The company's net revenue decreased to $13.9 million from $16.6 million year-over-year, yet the stock price remained steady at $2.06 in aftermarket trading. The upcoming launch of Exxua, a new antidepressant, and a focus on operational efficiency were key highlights of the call. Key Takeaways Aytu BioPharma's net revenue fell to $13.9 million, down from $16.6 million the previous year. The company is gearing up for the December 2025 launch of Exxua, a new antidepressant. Operating expenses were reduced to $10.2 million, enhancing financial efficiency. The stock price remained stable at $2.06 after the earnings call. Aytu holds a strong cash position with $32.6 million in cash and equivalents. Company Performance Aytu BioPharma's overall performance in the first quarter of 2025 was marked by a decrease in net revenue to $13.9 million, primarily due to a decline in gross margin from 72% to 66%. Despite this, the company's focus on reducing operating expenses and maintaining a strong cash position demonstrates a commitment to financial stability. The company is preparing for the launch of Exxua, which is anticipated to drive future growth. Financial Highlights Revenue: $13.9 million, down from $16.6 million year-over-year. Earnings per share: $0.21. Gross margin: 66%, compared to 72% the previous year. Cash and cash equivalents: $32.6 million. Outlook & Guidance Aytu BioPharma is optimistic about the launch of Exxua in December 2025, which is expected to significantly impact revenue in the March and June 2026 quarters. The company projects a break-even revenue of $17.3 million per quarter and anticipates a substantial investment of $10 million in the Exxua launch. Executive Commentary CEO Josh Disbrow expressed confidence in Exxua's potential, stating, "We are on the cusp of bringing to market what we believe is a game-changing opportunity for major depressive disorder." He emphasized the company's strategic focus, saying, "We will be hyper-focused. This will be a strict psychiatry play." Risks and Challenges The decline in net revenue and gross margin poses challenges to financial growth. The significant investment required for the Exxua launch could strain resources. Competitive pressures in the antidepressant market may impact Exxua's success. Market saturation and payer engagement strategies remain critical areas of focus. Economic conditions and regulatory changes could affect future performance. Full transcript - Aytu BioScience Inc (AYTU) Q1 2026: Operator: Greetings. Welcome to the Aytu BioPharma Fiscal 2026 Q1 Earnings Call. At this time, all participants are in a listen-only mode. A question-and-answer session will follow the formal presentation. If anyone should require operator assistance during the conference, please press star zero on your telephone keypad. Please note this conference is being recorded. I will now turn the conference over to your host, Robert Blum, with Investor Relations. You may begin. Robert Blum, Investor Relations, Aytu BioPharma: All right. Thank you very much, and good afternoon, everyone. As the operator indicated during today's call, we will be discussing Aytu BioPharma's Fiscal 2026 first quarter operational and financial results for the period ended September 30, 2025. Joining us on today's call is Aytu's Chief Executive Officer, Josh Disbrow, and Ryan Selhorn, the company's Chief Financial Officer. At the conclusion of today's prepared remarks, we'll open the call for a question-and-answer session. I'd like to remind everyone that today's call is being recorded. A replay of today's call will be available by using the telephone numbers and conference ID provided in the press release issued earlier today or by utilizing the link on the company's website under Events and Presentations. Finally, I'd also like to call to your attention the customary safe harbor disclosure regarding forward-looking information. The conference call today will contain certain forward-looking statements, including statements regarding the goals, strategies, beliefs, expectations, and future potential operating results of Aytu BioPharma. Although management believes these statements are reasonable based on estimates, assumptions, and projections as of today, these statements are not guarantees of future performance. Time-sensitive information may no longer be accurate at the time of any telephonic or webcast replay. Actual results may differ materially as a result of risks, uncertainties, and other factors, including, but not limited to, the factors set forth in the company's filings with the SEC. Aytu undertakes no obligation to update or revise any of these forward-looking statements. With that said, let me turn the call over to Josh Disbrow, Chief Executive Officer of Aytu BioPharma. Josh, please proceed. Josh Disbrow, Chief Executive Officer, Aytu BioPharma: Thank you, Robert, and welcome, everyone. I'm excited to be speaking with you on the heels of a very positive and highly productive first quarter. Let's jump into the high-level highlights. First off, net revenue for the quarter was $13.9 million. This was above our expectations as our ADHD portfolio has really continued to perform well. In fact, the ADHD portfolio net revenue was essentially up 10% compared to the year-ago period when excluding the one-time commercial rebate benefit we received a year ago. ADHD revenue was also up on a sequential basis. At a time when investors perhaps had expected a pullback in ADHD sales due to the threat of a generic launch and our shifting focus to Exxua launch preparations, we are actually experiencing net revenue growth. This is quite impressive and really reinforces our long-held belief on the added stickiness and positive economic benefits that are inherent in our A2Rx Connect platform, through which, I'll remind you, approximately 85% of our branded ADHD prescriptions are dispensed. I'll dive into this more in a moment. First, and perhaps even more important, is that the Exxua launch remains on track to occur by the end of calendar 2025, with significant advancements being made to ensure success, including KOL engagement, Salesforce training, product positioning, messaging, campaign development, and pricing, payer assessments, and integration within RS Connect. We continue to believe Exxua is a game-changing opportunity for Aytu, and the past few months have really reinforced that belief. Let's dive into our Aytu—excuse me, let's dive into our Exxua launch execution initiatives in more detail. First off, we're finalizing product manufacturing, labeling, serialization, and shipment to the company's third-party logistics provider, with the initial shipments on track for delivery in December of 2025. In many ways, this has been the biggest gating item to launch, and it remains on track. We are nearing completion of Salesforce training and have our formal launch meeting scheduled to take place in January of 2026. That said, leading up to the launch meeting, our reps are and will continue to be in the field talking with and preparing physicians and setting up appointments, etc., with the full Salesforce launching product stocking, following launch stocking, and the launch meeting. The product positioning, preparation of the promotional campaign, inclusive of promotional materials, refinement of physician messaging, and development of patient support materials is also nearing completion. We are implementing a comprehensive promotional program whereby we're establishing a clear positioning for Exxua based on its attributes, the competitive landscape, and ultimately where we believe we can win with the product. We have completed refinement of the sales territory alignments with physician targeting also essentially complete. We are maintaining a Salesforce of approximately 40 people, the same as what we have had historically with ADHD, but have altered some territories to ensure maximum reach while also aligning with where market access is expected to be strongest and prescribing potential is expected to be the highest. Remember, for government payers, major depressive disorder has nearly universal coverage as this condition is a federally mandated protected class whereby MDD prescriptions must be covered. This government segment represents approximately 30-40% of MDD-covered lives depending on the geography. With 30%-40% of the antidepressant category covered by virtue of this protected status, we are aligning sales territories appropriately to ensure optimal patient access with respect to both government and commercial payers. Further to that point, we've also established product pricing that is in line with or at a premium to other unique psychiatric treatments. We are also finalizing integration of Exxua into our A2Rx Connect patient access platform. We expect to drive distribution through and dispensing from our RS Connect network pharmacies as we do now with our ADHD portfolio. This will enable us to gain strong insights on reimbursement and coverage rates to help guide selective and smart payer contracting, which we will consider as the product launch gets underway. Employing RS Connect will also help ensure minimal friction with new prescribers of Exxua as it relates to coverage and the typical barriers they face when prescribing new brands. The final key launch activity has been the ramp-up in our key opinion leader engagement. Exxua has a long history of peer-reviewed publications, and that was added to recently by yet another peer-reviewed article discussing gepirone and the class of 5-HT1A agonists. Further, we recently attended our first medical conference, the Neuroscience Education Institute Fall Conference in Colorado Springs. The response to Exxua was tremendous. Led by our Senior Vice President of Scientific Affairs, Dr. Guerlin Westfield, we will continue to be proactive in our broader education of Exxua to the medical community and engagement with the scientific community. Finally, as most of you likely saw, we were successful in getting the Exxua method of use patent for Exxua extended to September of 2030. The patent extension further expands upon the new chemical entity exclusivity period. Beyond the 2030 date, we are engaged in discussions to expand upon the existing intellectual property through various potential lifecycle management approaches, which might extend exclusivity beyond 2030. This is all to say we are laser-focused on the successful commercial launch of Exxua as we focus on positively impacting the lives of an estimated 21 million Americans with major depressive disorder. Our entire team is beyond thrilled as we collectively believe Exxua is quite simply transformational for Aytu. Turning back quickly to the ADHD portfolio. As most of you know, there has been a long-since negotiated Paragraph 4 settlement agreement with Teva, whereby they were allowed to enter the market with a generic to Xenace back on September 1. As we sit here today, on November 13, more than two months after they were eligible to have entered, they have yet to launch. We talked about this during our last earnings call, but to quickly summarize, it's been our long-standing belief that the impact to our ADHD franchise, even if Teva does enter, will not be as significant as you might see with other products sold via traditional retail distribution. The reasons for this are multifold, but include, one, the fact that, again, approximately 85% of our ADHD prescriptions run through our RS Connect platform, not through regular way retail like CVS or Walgreens. This system is quite unique and dramatically alters the normal way in which generics might try to compete on pricing and spread. Two, the ADHD category is already a highly genericized market with minimal switching. Opportunities have existed for many years to prescribe and fill alternatives like generic Adderall XR, yet we've held a consistent share of the market for multiple years. Third, the gross to nets on our ADHD portfolio are already below what industry observers might expect when generics typically enter the market. Price erosion has already largely occurred by virtue of the fact that we discount significantly to overcome patient pricing objections in a highly genericized market. This is to say that the substitution impact and transition to a generic market and subsequently to a generic price is not nearly as high as you might see in other situations. Fourth, we launched our own authorized generic of Xenace on September 2. This AG will serve as an important offensive tool in what we believe will help us maintain a material share of the Xenace market irrespective of a potential generic entry by having a truly equivalent version of a product available that is sold as a generic. Importantly, our AG is already off to a very good start, representing a significant share of the prescriptions after just two months on the market. We know it is still early, but we continue to believe that anyone's projections of a worst-case scenario for broader impact to our ADHD franchise are unlikely, but clearly, we will continue to monitor things. One more quick note before I turn it over to Ryan to review the financials in more detail. As some of you may have seen, on October 31, the FDA put out a communication regarding their position on fluoride-containing drugs and some potential regulatory action. This has been anticipated for some time, and we've communicated this to you during past calls. We continue to monitor the situation, but note importantly that Aytu has not received any direct communication from the agency seeking action on our fluoride products. Even in the event FDA ultimately pursues any action, it's important to note that this is a very small portion today of our overall business. During the quarter, fluoride products amounted to only about $300,000 in revenue. Importantly, our infant drops product line represents only approximately $1.4 million when looking at the trailing 12-month period ending September 30. Any potential impact will not have a sizable impact on our financials, given that any agency action would likely center only on the fluoride liquid drops for the youngest patients. Also importantly, following the FDA's October 31st communications on fluoride supplementation, the American Dental Association issued yet another press release that clearly supports supplementation, and the association doubled down and continued with their recommendation to continue with fluoride supplementation in areas where fluoridated water either does not exist or has inadequate levels of fluoride. Again, we will continue to monitor the situation. With that, let me turn the call over to Ryan to go into more detail on the financials. I will then make a few closing comments and look to address any questions you might have. Ryan? Ryan Selhorn, Chief Financial Officer, Aytu BioPharma: Thank you, Josh. Let's jump right into it. Let's start on the revenue line. Net revenue for the quarter was $13.9 million compared to $16.6 million for the prior year. As mentioned in the press release, the year-ago quarter included a one-time benefit due to an accrued rebate liability settlement related to the ADHD portfolio of $3.3 million, which resulted in an increase in the Q1 fiscal 2025 net revenue of $3.3 million. We highlighted this item last year as well. Excluding the rebate on an apples-to-apples basis, net revenue would have actually increased 5% compared to the year-ago quarter. Breaking net revenue down, the ADHD portfolio net revenue was $13.2 million compared to $15.3 million in the prior year period. Excluding the rebate, the year-ago quarter would have been $11.9 million, highlighting net revenue increasing for our ADHD portfolio of about 10% on an equivalent basis. The increase is attributable partially to product price increases during the past year and improved gross to nets, offset by a decrease in total prescriptions. The pediatric portfolio was $0.7 million for the first quarter compared to $1.3 million last year. The change in net revenue is attributable to manufacturing delays with one of our suppliers, which we are in the process of being resolved, as well as multivitamin product returns and a broader de-emphasis in marketing toward the pediatric portfolio in anticipation of the recent actions by the administration and the FDA. Gross margin was 66% during the quarter compared to 72% last year. Again, the rebate here flowed entirely through the gross profit line as well. On an equivalent basis, gross margin during the year-ago period would have been 65%. We actually saw a gross margin improvement from the year-ago period when excluding the rebate. Turning to OpEx, operating expenses excluding amortization of intangible assets and restructuring costs was $10.2 million in the first quarter compared to $11.2 million in the prior year period. This $10.2 million figure also includes about $100,000 in depreciation and stock compensation. So the cash OpEx number is about $10.1 million. The decrease is primarily a result of continued cost reduction efforts and improved operational efficiencies as part of the company's overall strategic realignment, offset by increased Exxua launch investments. When you look at the modeling of expenses going forward, we anticipate that our baseline total operating expense level, inclusive of amortization and depreciation, will remain at about that $10 million per quarter. Then, added to that, we will have an incremental investment of about $10 million on the launch of Exxua this fiscal year. All in, that is about a $50 million OpEx number for the fiscal 2026. Importantly, of the $10 million of Exxua investment this year, about $6 million of that is sort of one-time items, such as training development, commercial and medical affairs consultants, and campaign and marketing materials development. The bulk of this spend will be in our December and March ending quarters from a one-time perspective. Going forward, we will certainly adjust our spend as the ramp of Exxua continues, but think of our exiting the fiscal year at about an $11.4 million quarterly normalized run rate with about $500,000 of that in non-cash expenses. Assuming gross margins in this mid to high 60% range, that puts our break-even at about $17.3 million of net revenue per quarter all in, including Exxua spends. Cash break-even would be $16.6 million per quarter. For the quarter, we reported a net income of $2 million or $0.21 net income per share basic compared to net income of $1.5 million or $0.24 net income per share basic in the prior year period. The fiscal 2026 and fiscal 2025 first quarter results were impacted by derivative warrant liability gains of $3.8 million and $2.9 million, respectively, primarily due to a change in the company's stock price. As mentioned earlier, the prior year first quarter benefited by $3.3 million due to the rebate liability adjustment, which directly increased net income. I'll touch on the warrant liability in a moment, but this is largely due to the pre-funded warrants issued in the Exxua transaction. Finally, adjusted EBITDA was a negative $0.6 million for the first quarter of fiscal 2026 compared to a positive $1.9 million in the year-ago period. The change primarily relates to the benefit we received in the year-ago period from the rebate, as well as Exxua launch investments, which took place in the first quarter of this year. Now turning to the balance sheet, cash and cash equivalents were $32.6 million at September 30, 2025. This compares to $31 million at June 30, 2025. A couple of other small notes on the balance sheet. We continue to pay down some higher interest liabilities during the quarter, namely the TRIS fixed payment arrangement. You will see that the other current liabilities line went from $3.4 million in June to $200,000 this quarter. This has resulted in a substantial decrease in interest expense from $1 million in the prior year quarter to $500,000 in the current year quarter. While we do not anticipate $500,000 of savings each quarter, we should see continued savings throughout the fiscal 2026. The rest of the balance sheet is pretty much in line with where it was last quarter. Circling back to my comment on the derivative warrant liability gain, as you may recall, the financing transaction we completed in connection with the Exxua acquisition was basically a straight common stock deal, but it did have pre-funded warrants issued due to ownership percentage blockers. This does cause gyrations to the income statement based on the movement of our stock price, which creates gains or losses to the derivative warrant liabilities line each quarter. On the balance sheet, those warrants are treated as liability until they are converted to common shares, at which time they will move to additional paid-in capital. During the quarter, there were 935,000 pre-funded warrants exercised, which effectively added $2.1 million to APIC. As we sit today, there are 10.2 million common shares outstanding, plus an additional 9.4 million pre-funded warrants outstanding, which effectively puts us at a 19.6 million shares outstanding. Before I turn it back over to Josh to reconfirm what we communicated last late September during our call at year-end, let me spend a few minutes walking through some of the assumptions we have on Exxua for the remainder of the year. To be clear, there have been no changes to what we mentioned during the last call. I simply want to make sure anyone that missed it has the information handy. As discussed, we plan to launch Exxua in the fourth quarter of calendar 2025, which is our second fiscal quarter of 2026, or the December 2025 ending quarter. This will be the initial product load-in. We would not expect there to be any significant revenue to report during the second fiscal quarter. The launch will continue into the March 2026 quarter, where we expect to see some initial ramp in revenue, but the real story is expected to occur during the June 2026 quarter and beyond. From a gross margin perspective, as a reminder, we have a 28% royalty on Exxua in addition to a true-up on cost of goods sold. Think of it, in essence, as a 31% cost of goods sold or 69% gross contribution margin. We do anticipate some fixed expenses to be incurred in cost of goods sold following the launch. However, the upfront fee, post-launch fee, and any milestone payments will be reported as an intangible asset and amortized to the operating expenses starting once we launch the product. As I noted earlier, from an OpEx perspective, we expect to invest approximately $10 million in the initial launch of Exxua here in fiscal 2026. This was well-defined in the plans heading into the product acquisition and financing that we conducted, and we expect this puts us in a good cash position as Exxua begins to ramp as we exit fiscal 2026. As always, happy to go over any details during Q&A. With that, Josh, let me turn it back over to you. Josh Disbrow, Chief Executive Officer, Aytu BioPharma: Thanks, Ryan. I want to make sure we leave time for questions, so let me wrap up here quickly, and then I'll turn it over to you for questions. Simply put, we were on the cusp of bringing to market what we believe is a game-changing opportunity for major depressive disorder. Every physician survey conducted, whether by us or independently, has shown almost universally that once available, physicians have patients for whom they will prescribe Exxua due to its effectiveness in treating the symptoms of depression without inducing critical side effects such as sexual dysfunction and weight gain. As I've said in the past, nowhere in the package insert are the words sexual dysfunction mentioned, a claim virtually no other MDD pharmaceutical treatment can make. We think this is critical. Further, Exxua is weight neutral and doesn't increase anxiety. To additional product features, we and our surveyed prescribers view as extremely valuable and also distinct from many other treatment options. While we think the peak sales for this product are extremely high, the reality is that even if this does a fraction of what many of the competing products in the market do, or if we receive just a fraction of the scripts written that our ADHD drugs have, this is a huge opportunity for Aytu and for our shareholders. The coming months are very exciting for Aytu. We're laser-focused on the launch and success of Exxua and look forward to getting this into the hands of physicians in the months to come. As always, I want to thank everyone participating on today's call. We'll now be happy to answer any questions. Operator? Operator: Certainly. At this time, we will be conducting a question-and-answer session. If you would like to ask a question, please press Star 1 on your telephone keypad. A confirmation tone will indicate your line is in the question queue. You may press Star 2 if you would like to remove your question from the queue. For participants using speaker equipment, it may be necessary to pick up the handset before pressing the Star keys. One moment, please, while we poll for questions. Your first question for today is from Thomas Flatten with Lake Street Capital. Thomas Flatten, Analyst, Lake Street Capital: Hey, good afternoon, guys. Congrats on the quarter. Josh, I was wondering if you could comment on how significant, or maybe how many territories were affected by the realignment. Part two of that question is, how are you thinking about an incentive comp plan post-Exxua launch? Josh Disbrow, Chief Executive Officer, Aytu BioPharma: Yeah, good questions. Thank you. Just writing those down. Thanks for those questions, Thomas. How many territories affected? In whole or in part, off the top of my head, it's probably no more than about a third of the territories have been maybe altered or reshaped. We have gone denser in some areas where we fully expect substantially better coverage than we have for ADHD meds and actually really favorable coverage. I think of it as probably about a third in one way, shape, or form. Some were modestly affected, a few zip codes here or there. Others were more materially affected, but probably in that range. In terms of IC, very rich IC plan still being finalized, but we will certainly incentivize very, very heavily around Exxua, activating new psychiatrists, getting new offices set up, and then obviously rewarding for going deeper within those prescribers as well. To incentivize to get them turned on and initially utilizing Exxua, and then obviously incentives to get repeat prescribing as they identify more and more patients. We will be hyper-focused. As we've said in the past, this will be a strict psychiatry play. We'll be in offices that are housing psychiatrists and psychiatry nurse practitioners and PAs, and that's really where the density of the prescribing for the brands in this category happens. That's the right place to be. Thomas Flatten, Analyst, Lake Street Capital: If I may, one more. What have you been doing pre-launch with respect to payer engagement? Is that something you've been doing? And what expectations do you have for coverage improving beyond the kind of protective Medicare component of it? Josh Disbrow, Chief Executive Officer, Aytu BioPharma: Yeah, good question. For us, first, second, and third, around anything related to particularly commercial payers for us is wait and see. We're not going to proactively contract so as to jeopardize best price that we'll have afforded to us on the government side. As you know, with the mandate to cover antidepressants, we'll have, we think, a pretty wide open field, particularly in at least a handful of states, and we'll be able to have open access with the standard 23.1% rebate to the Medicaid plans in particular. As we think about that and we think about the portion of the business that is likely to represent, call that 30-40%, depending on the geography, we want to be very judicious in how we think about contracting on the commercial side so as not to reset that best price. That is all to say we have done assessments. We do have had some light engagement with commercial payers. We are reluctant to do anything at the outset until we get a sense for exactly what coverage rate looks like, exactly what the lay of the land is, and we'll have that access through RxConnect. That having been said, if you look at precedent products, a good one of which is Auvelity, marketed by Axsome Therapeutics, as you know, that product enjoys 100% coverage on the government side, and last we checked, in the range of 70% coverage on the commercial side, and that's with what we perceive to be very limited direct contracting, perhaps with one PBM. Using that as a bit of a guidepost, we will be very judicious, but we would still, out of the gate, expect enormously better coverage for Exxua than we have for our ADHD meds, and of course, just higher price points in general when you look at net pricing by virtue of the coverage on both the commercial and the government side. Hopefully that answers your question, but we are not one to go out and announce a bunch of deals with payers that, frankly, may not be worth the paper they're written on. We'd rather take it one step at a time, utilize the Rx Connect mechanisms to optimize reimbursement on the pharmacy front while obviously minimizing the copay and the hassle on the patient front. That's how we'll approach it. Not to say we'll never contract. We'll certainly look at it, but we'll be very judicious, but want to make sure we approach it in the right way. Thomas Flatten, Analyst, Lake Street Capital: That's great. I appreciate it. Thanks, guys. Josh Disbrow, Chief Executive Officer, Aytu BioPharma: Thank you. Operator: Your next question for today is from Naz Rahman with Maxim Group. Naz Rahman, Analyst, Maxim Group: Hi everyone. Congrats on the progress, and thanks for taking my questions. I understand you haven't initiated the full launch yet, but thus far, how much of your target prescriber market have you reached out to, and what kind of feedback have you gotten from that prescriber market thus far? Josh Disbrow, Chief Executive Officer, Aytu BioPharma: Yeah, good question. I would say probably second question first, which is nearly universally positive when you look at the doctors that we're most actively engaged with. The sweet spot for us in terms of targets is psychiatrists in our footprint that are already comfortable with our products and with RxConnect, and when you overlay sort of those three criteria, you get an overwhelmingly positive response. In terms of the % of the market that we've reached out to, still relatively small by virtue of the fact that we're trying to be hyper-focused in the areas where we know we can be successful. Again, these are physician customers that are already fans of ours. They already prescribe Adzenys, Cotempla in many cases to the tunes of hundreds of prescriptions a week or, sorry, a month or a quarter, and thousands over the course of a year. That is really where we want to start. We think by really kind of tripling down and not trying to spread ourselves all over and try to be all things to all people, let's be very focused and very concentrated with who we think will be the most likely to prescribe. These are doctors, again, in our geographies, like our products, utilize our pharmacy partners. They also prescribe the newer products like Auvelity and Trintellix and Spravato. You put all those things together, and we think that is going to lead to a relatively highly accelerated launch, and then we will expand out from there. Naz Rahman, Analyst, Maxim Group: Thanks. That was helpful. Based on the feedback you have gotten thus far from the limited physicians, have you been able to build out what a target patient profile might look like or what kind of patients that these physicians might initially treat or attempt to treat with Exxua? Josh Disbrow, Chief Executive Officer, Aytu BioPharma: We have, and this is part of our communications and part of our materials, but it's a younger patient in the prime of their life seeking to improve their life and, by virtue of that, minimize the side effects they may be experiencing on current medication. We would rightly be targeting patients that have been on a therapy or two or three and remain dissatisfied largely due to the side effects they're experiencing with respect to sexual dysfunction and weight gain. Before they would go to another therapy that maybe has less incidence of sexual side effects, we would insert ourselves in there and say, for that younger patient, when I say younger, 18 to 50, I just turned 50, so I'd like to think of myself as still in that demographic, those are patients ideally suited to be switched from an SSRI or an SNRI that, again, might be working to some degree, but is leaving them dissatisfied from a side effect perspective. That is the type of profile that we'll be starting with. Again, we want to be very specific. We do not want to go in and ask a physician for all of his or her patients. That is not realistic. It's not going to be really allowable by virtue of just the market dynamics and just the standardization of care, given that 99 times out of 100 patients will start on an SSRI or SNRI, and the payers, by the way, will require that. We will be looking for that switch after that. Honestly, even if we get the switch after that switch or after the switch after that, that is a huge funnel of patients to be starting with, even if we're talking third, fourth, fifth, sixth, or even later line. Just such a big market opportunity with 340-plus million prescriptions annually, and at the price point that we would anticipate netting, that's a huge opportunity for us, even if it's used much later line. Naz Rahman, Analyst, Maxim Group: Got it. Thanks for taking my questions. Josh Disbrow, Chief Executive Officer, Aytu BioPharma: Thank you. Operator: Once again, if you would like to ask a question, please press Star 1. Your next question is from Ed Wu with Ascendent Capital. Josh Disbrow, Chief Executive Officer, Aytu BioPharma: Yeah, congratulations on all the progress. My question specifically is on your supply chain. How quickly and flexible are you to ramp up if demand is greater than you expect? What is your leverage opportunity, margin opportunity to get if you do get to a certain scale in terms of your margin expansion? I'll take the first one, Ed, and hand the second one to Ryan in terms of margin expansion. I would say, generally speaking, we have flexibility. We are working through a contract manufacturer, but there is enough supply produced for, I would say, an outsized forecast even versus what we have as a base case. We have enough produced and sitting in bulk, not yet packaged, but sitting in bulk that's multiples higher than our first 24-month forecast. Our first 24-month forecast, I wouldn't call conservative. We have adequate supply to scale as needed. There is also API already in hand to enable us to accelerate production of sort of a second run. Plenty of product to get us started, plenty of product to ramp, again, by multiples in the event that we need to. In terms of opportunities for margin expansion, maybe Ryan, you can just share generally how the margin works and kind of the sales level at which we would potentially start to see a reduction in royalty. Naz Rahman, Analyst, Maxim Group: Yep, absolutely. As I mentioned, we have a 28% royalty. That is not obviously related to the manufacturing of the product, but that will drop down to 24% once we hit about $1.3 billion in aggregate sales. The actual cost of the product is only about, we are projecting about 2% of the net revenue per product per unit. It is pretty small to begin with. If we were to size up the batches, there is a little bit of efficiency, but it is not an expensive drug to produce in the outfront. Josh Disbrow, Chief Executive Officer, Aytu BioPharma: Great. Thanks for answering my questions, and I wish you guys good luck. Thank you. Thank you. Operator: We have reached the end of the question and answer session, and I will now turn the call over to management for closing remarks. Josh Disbrow, Chief Executive Officer, Aytu BioPharma: Thanks very much, everyone, for joining us on today's call. Very excited about the progress we're making as we are on the precipice of launching Exxua. The next time we'll talk will be in February, at which time we fully expect to be in the field having announced our full commercial launch. Until that time, we'll be very busy getting things ready and, again, continue to have a high level of excitement around this opportunity to help these many millions of patients fighting major depressive disorders. With that, thanks again for joining, and we'll look forward to updating you after our second quarter wraps up on our quarterly call in February. Thanks very much, and have a good evening. Operator: This concludes today's conference, and you may disconnect your lines at this time. Thank you for your participation.
  Content Reference URL	None

• Publisher

  Publisher Name	Investing.com (#43)
  Publisher URL	https://www.investing.com
  Description	None
  Trust Flow Score	37
  Citation Flow Score	46

• Data Source

  Data Source Name	NewsCatcher (#303)
  Data Source Type	news
  Data Source URL	https://www.newscatcherapi.com/
  Description
  Weight	1